Squalene Synthase As a Target for Chagas Disease Therapeutics

Trypanosomatid parasites are the causative agents of many neglected tropical diseases and there is currently considerable interest in targeting endogenous sterol biosynthesis in these organisms as a route to the development of novel anti-infective drugs. Here, we report the first x-ray crystallograp...

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Detalles Bibliográficos
Autores principales: Shang, Na, Li, Qian, Ko, Tzu-Ping, Chan, Hsiu-Chien, Li, Jikun, Zheng, Yingying, Huang, Chun-Hsiang, Ren, Feifei, Chen, Chun-Chi, Zhu, Zhen, Galizzi, Melina, Li, Zhu-Hong, Rodrigues-Poveda, Carlos A., Gonzalez-Pacanowska, Dolores, Veiga-Santos, Phercyles, de Carvalho, Tecia Maria Ulisses, de Souza, Wanderley, Urbina, Julio A., Wang, Andrew H.-J., Docampo, Roberto, Li, Kai, Liu, Yi-Liang, Oldfield, Eric, Guo, Rey-Ting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4006925/
https://www.ncbi.nlm.nih.gov/pubmed/24789335
http://dx.doi.org/10.1371/journal.ppat.1004114

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4006925/
https://www.ncbi.nlm.nih.gov/pubmed/24789335
http://dx.doi.org/10.1371/journal.ppat.1004114

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