The c-Abl inhibitor, Nilotinib, protects dopaminergic neurons in a preclinical animal model of Parkinson's disease

c-Abl is activated in the brain of Parkinson's disease (PD) patients and in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-intoxicated mice where it inhibits parkin through tyrosine phosphorylation leading to the accumulation of parkin substrates, and neuronal cell death. In the present st...

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Detalles Bibliográficos
Autores principales: Karuppagounder, Senthilkumar S., Brahmachari, Saurav, Lee, Yunjong, Dawson, Valina L., Dawson, Ted M., Ko, Han Seok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4007078/
https://www.ncbi.nlm.nih.gov/pubmed/24786396
http://dx.doi.org/10.1038/srep04874

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4007078/
https://www.ncbi.nlm.nih.gov/pubmed/24786396
http://dx.doi.org/10.1038/srep04874

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