Small molecule MIRA-1 induces in vitro and in vivo anti-myeloma activity and synergizes with current anti-myeloma agents

BACKGROUND: Small molecule MIRA-1 induced mutant p53-dependent apoptosis in several types of solid tumours. However, anti-tumour activity of MIRA-1 in haematological malignancies including multiple myeloma (MM) is unknown. In this study, we evaluated the effect of MIRA-1 in MM. METHODS: We examined...

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Detalles Bibliográficos
Autores principales: Saha, M N, Chen, Y, Chen, M-H, Chen, G, Chang, H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Translational Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4007239/
https://www.ncbi.nlm.nih.gov/pubmed/24691427
http://dx.doi.org/10.1038/bjc.2014.164

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4007239/
https://www.ncbi.nlm.nih.gov/pubmed/24691427
http://dx.doi.org/10.1038/bjc.2014.164

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