Prospective neoadjuvant analysis of PET imaging and mechanisms of resistance to Trastuzumab shows role of HIF1 and autophagy

BACKGROUND: Although Trastuzumab has improved survival of HER2+ breast cancer patients, resistance to the agent pre-exists or develops through the course of therapy. Here we show that a specific metabolism and autophagy-related cancer cell phenotype relates to resistance of HER2+ breast cancer to Tr...

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Detalles Bibliográficos
Autores principales: Koukourakis, M I, Giatromanolaki, A, Bottini, A, Cappelletti, M R, Zanotti, L, Allevi, G, Strina, C, Ardine, M, Milani, M, Brugnoli, G, Martinotti, M, Ferrero, G, Bertoni, R, Ferrozzi, F, Harris, A L, Generali, D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Clinical Study
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4007245/
https://www.ncbi.nlm.nih.gov/pubmed/24722179
http://dx.doi.org/10.1038/bjc.2014.196

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4007245/
https://www.ncbi.nlm.nih.gov/pubmed/24722179
http://dx.doi.org/10.1038/bjc.2014.196

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