An atrial-fibrillation-linked connexin40 mutant is retained in the endoplasmic reticulum and impairs the function of atrial gap-junction channels

Connexin40 (Cx40)-containing gap-junction channels are expressed in the atrial myocardium and provide a low-resistance passage for rapid impulse propagation. A germline mutation in the GJA5 gene, which encodes Cx40, resulting in a truncated Cx40 (Q49X) was identified in a large Chinese family with l...

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Detalles Bibliográficos
Autores principales: Sun, Yiguo, Tong, Xiaoling, Chen, Honghong, Huang, Tao, Shao, Qing, Huang, Weixiong, Laird, Dale W., Bai, Donglin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Limited 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4007407/
https://www.ncbi.nlm.nih.gov/pubmed/24626989
http://dx.doi.org/10.1242/dmm.013813

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4007407/
https://www.ncbi.nlm.nih.gov/pubmed/24626989
http://dx.doi.org/10.1242/dmm.013813

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