Mouse models of telomere dysfunction phenocopy skeletal changes found in human age-related osteoporosis

A major medical challenge in the elderly is osteoporosis and the high risk of fracture. Telomere dysfunction is a cause of cellular senescence and telomere shortening, which occurs with age in cells from most human tissues, including bone. Telomere defects contribute to the pathogenesis of two proge...

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Detalles Bibliográficos
Autores principales: Brennan, Tracy A., Egan, Kevin P., Lindborg, Carter M., Chen, Qijun, Sweetwyne, Mariya T., Hankenson, Kurt D., Xie, Sharon X., Johnson, Frederick B., Pignolo, Robert J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Limited 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4007409/
https://www.ncbi.nlm.nih.gov/pubmed/24626990
http://dx.doi.org/10.1242/dmm.014928

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4007409/
https://www.ncbi.nlm.nih.gov/pubmed/24626990
http://dx.doi.org/10.1242/dmm.014928

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