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Mouse models of telomere dysfunction phenocopy skeletal changes found in human age-related osteoporosis
A major medical challenge in the elderly is osteoporosis and the high risk of fracture. Telomere dysfunction is a cause of cellular senescence and telomere shortening, which occurs with age in cells from most human tissues, including bone. Telomere defects contribute to the pathogenesis of two proge...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Company of Biologists Limited
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4007409/ https://www.ncbi.nlm.nih.gov/pubmed/24626990 http://dx.doi.org/10.1242/dmm.014928 |