Cargando…

Gene Family Level Comparative Analysis of Gene Expression in Mammals Validates the Ortholog Conjecture

The ortholog conjecture (OC), which is central to functional annotation of genomes, posits that orthologous genes are functionally more similar than paralogous genes at the same level of sequence divergence. However, a recent study challenged the OC by reporting a greater functional similarity, in t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rogozin, Igor B., Managadze, David, Shabalina, Svetlana A., Koonin, Eugene V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4007545/ https://www.ncbi.nlm.nih.gov/pubmed/24610837 http://dx.doi.org/10.1093/gbe/evu051

Ejemplares similares

Negative Correlation between Expression Level and Evolutionary Rate of Long Intergenic Noncoding RNAs
por: Managadze, David, et al.
Publicado: (2011)

Testing the Ortholog Conjecture with Comparative Functional Genomic Data from Mammals
por: Nehrt, Nathan L., et al.
Publicado: (2011)

MitoCOGs: clusters of orthologous genes from mitochondria and implications for the evolution of eukaryotes
por: Kannan, Sivakumar, et al.
Publicado: (2014)

The Vast, Conserved Mammalian lincRNome
por: Managadze, David, et al.
Publicado: (2013)

Conservation of the Exon-Intron Structure of Long Intergenic Non-Coding RNA Genes in Eutherian Mammals
por: Chernikova, Diana, et al.
Publicado: (2016)

The ortholog conjecture revisited: the value of orthologs and paralogs in function prediction
por: Stamboulian, Moses, et al.
Publicado: (2020)

Transposable Element Insertions in Long Intergenic Non-Coding RNA Genes
por: Kannan, Sivakumar, et al.
Publicado: (2015)

The Ortholog Conjecture Is Untestable by the Current Gene Ontology but Is Supported by RNA Sequencing Data
por: Chen, Xiaoshu, et al.
Publicado: (2012)

Accumulation of GC donor splice signals in mammals
por: Churbanov, Alexander, et al.
Publicado: (2008)

Correction: The Ortholog Conjecture Is Untestable by the Current Gene Ontology but Is Supported by RNA Sequencing Data
por: Chen, Xiaoshu, et al.
Publicado: (2013)

Mimiviridae: clusters of orthologous genes, reconstruction of gene repertoire evolution and proposed expansion of the giant virus family
por: Yutin, Natalya, et al.
Publicado: (2013)

Resolving the Ortholog Conjecture: Orthologs Tend to Be Weakly, but Significantly, More Similar in Function than Paralogs
por: Altenhoff, Adrian M., et al.
Publicado: (2012)

Generalized Portrait of Cancer Metabolic Pathways Inferred from a List of Genes Overexpressed in Cancer
por: Poliakov, Eugenia, et al.
Publicado: (2014)

Connections between Alternative Transcription and Alternative Splicing in Mammals
por: Shabalina, Svetlana A., et al.
Publicado: (2010)

Prokaryotic Virus Orthologous Groups (pVOGs): a resource for comparative genomics and protein family annotation
por: Grazziotin, Ana Laura, et al.
Publicado: (2017)

An apology for orthologs - or brave new memes
por: Koonin, Eugene V
Publicado: (2001)

Selection in the evolution of gene duplications
por: Kondrashov, Fyodor A, et al.
Publicado: (2002)

Patterns of intron gain and conservation in eukaryotic genes
por: Carmel, Liran, et al.
Publicado: (2007)

Updated clusters of orthologous genes for Archaea: a complex ancestor of the Archaea and the byways of horizontal gene transfer
por: Wolf, Yuri I, et al.
Publicado: (2012)

Evolution of alternative and constitutive regions of mammalian 5'UTRs
por: Resch, Alissa M, et al.
Publicado: (2009)

A highly conserved family of inactivated archaeal B family DNA polymerases
por: Rogozin, Igor B, et al.
Publicado: (2008)

The rhomboids: a nearly ubiquitous family of intramembrane serine proteases that probably evolved by multiple ancient horizontal gene transfers
por: Koonin, Eugene V, et al.
Publicado: (2003)

Evolution of mosaic operons by horizontal gene transfer and gene displacement in situ
por: Omelchenko, Marina V, et al.
Publicado: (2003)

Evolution at protein ends: major contribution of alternative transcription initiation and termination to the transcriptome and proteome diversity in mammals
por: Shabalina, Svetlana A., et al.
Publicado: (2014)

ATGC: a database of orthologous genes from closely related prokaryotic genomes and a research platform for microevolution of prokaryotes
por: Novichkov, Pavel S., et al.
Publicado: (2009)

Clusters of orthologous genes for 41 archaeal genomes and implications for evolutionary genomics of archaea
por: Makarova, Kira S, et al.
Publicado: (2007)

Nonstructural p26 proteins encoded by the 3’-proximal genes of velariviruses and criniviruses are orthologs
por: Rogozin, I. B., et al.
Publicado: (2019)

Mutational hotspots in the TP53 gene and, possibly, other tumor suppressors evolve by positive selection
por: Glazko, Galina V, et al.
Publicado: (2006)

Eukaryotic large nucleo-cytoplasmic DNA viruses: Clusters of orthologous genes and reconstruction of viral genome evolution
por: Yutin, Natalya, et al.
Publicado: (2009)

Archaeal Clusters of Orthologous Genes (arCOGs): An Update and Application for Analysis of Shared Features between Thermococcales, Methanococcales, and Methanobacteriales
por: Makarova, Kira S., et al.
Publicado: (2015)

Evolutionary conservation suggests a regulatory function of AUG triplets in 5′-UTRs of eukaryotic genes
por: Churbanov, Alexander, et al.
Publicado: (2005)

Getting positive about selection
por: Koonin, Eugene V, et al.
Publicado: (2003)

Distinct Patterns of Expression and Evolution of Intronless and Intron-Containing Mammalian Genes
por: Shabalina, Svetlana A., et al.
Publicado: (2010)

The relation between the Baum-Connes conjecture and the trace conjecture
por: Lück, W
Publicado: (2001)

A Detailed History of Intron-rich Eukaryotic Ancestors Inferred from a Global Survey of 100 Complete Genomes
por: Csuros, Miklos, et al.
Publicado: (2011)

Impairment of translation in neurons as a putative causative factor for autism
por: Poliakov, Eugenia, et al.
Publicado: (2014)

Selection on start codons in prokaryotes and potential compensatory nucleotide substitutions
por: Belinky, Frida, et al.
Publicado: (2017)

A Tight Link between Orthologs and Bidirectional Best Hits in Bacterial and Archaeal Genomes
por: Wolf, Yuri I., et al.
Publicado: (2012)

The Bieberbach conjecture
por: Gong, Sheng
Publicado: (2014)

The Smith conjecture
por: Morgan, John W, et al.
Publicado: (1984)

Cannot write session to /tmp/vufind_sessions/sess_3l2q9f35lkid8d625qtfpgnm6d