Reversible, interrelated mRNA and miRNA expression patterns in the transcriptome of Rasless fibroblasts: functional and mechanistic implications

BACKGROUND: 4-Hydroxy-tamoxifen (4OHT) triggers Cre-mediated K-Ras removal in [H-Ras(-/-);N-Ras(-/-);K-Ras(lox/lox);RERT(ert/ert)] fibroblasts, generating growth-arrested “Rasless” MEFs which are able to recover their proliferative ability after ectopic expression of Ras oncoproteins or constitutive...

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Detalles Bibliográficos
Autores principales: Azrak, Sami S, Ginel-Picardo, Alicia, Drosten, Matthias, Barbacid, Mariano, Santos, Eugenio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4007593/
https://www.ncbi.nlm.nih.gov/pubmed/24156637
http://dx.doi.org/10.1186/1471-2164-14-731

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4007593/
https://www.ncbi.nlm.nih.gov/pubmed/24156637
http://dx.doi.org/10.1186/1471-2164-14-731

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