ATP directed agent, 8-chloro-adenosine, induces AMP activated protein kinase activity, leading to autophagic cell death in breast cancer cells

BACKGROUND: 8-chloro-adenosine (8-Cl-Ado) is a unique ribonucleoside analog which is currently in a phase I clinical trial for hematological malignancies. Previously, we demonstrated in breast cancer cells that a 3-day treatment with 10 μM 8-Cl-Ado causes a 90% loss of clonogenic survival. In contra...

Descripción completa

Detalles Bibliográficos
Autores principales: Stellrecht, Christine M, Vangapandu, Hima V, Le, Xiao-Feng, Mao, Weiqun, Shentu, Shujun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4007639/
https://www.ncbi.nlm.nih.gov/pubmed/24628795
http://dx.doi.org/10.1186/1756-8722-7-23

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4007639/
https://www.ncbi.nlm.nih.gov/pubmed/24628795
http://dx.doi.org/10.1186/1756-8722-7-23

Ejemplares similares