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Autophagy protects against human islet amyloid polypeptide‐associated apoptosis

Aims/Introduction:  Islets in type 2 diabetes are characterized by deposition of islet amyloid polypeptide (IAPP) as well as β‐cell dysfunction. The unique amyloidogenic character of human (h)IAPP is associated with cytotoxicity. Autophagy is a ubiquitous system of cellular recycling that contribute...

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Detalles Bibliográficos
Autores principales: Morita, Shuhei, Sakagashira, Setsuya, Shimajiri, Yoshinori, Eberhardt, Norman L, Kondo, Toshikazu, Kondo, Tomoyoshi, Sanke, Tokio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4008015/
https://www.ncbi.nlm.nih.gov/pubmed/24843461
http://dx.doi.org/10.1111/j.2040-1124.2010.00065.x