Activation of MAPK and FoxO by Manganese (Mn) in Rat Neonatal Primary Astrocyte Cultures

Environmental exposure to manganese (Mn) leads to a neurodegenerative disease that has shared clinical characteristics with Parkinson's disease (PD). Mn-induced neurotoxicity is time- and dose-dependent, due in part to oxidative stress. We ascertained the molecular targets involved in Mn-induce...

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Detalles Bibliográficos
Autores principales: Exil, Vernat, Ping, Li, Yu, Yingchun, Chakraborty, Sudipta, Caito, Samuel W., Wells, K. Sam, Karki, Pratap, Lee, Eunsook, Aschner, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4008430/
https://www.ncbi.nlm.nih.gov/pubmed/24787138
http://dx.doi.org/10.1371/journal.pone.0094753

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4008430/
https://www.ncbi.nlm.nih.gov/pubmed/24787138
http://dx.doi.org/10.1371/journal.pone.0094753

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