Altering the intratumoral localization of macrophages to inhibit cancer progression

Hypoxia confers to macrophages angiogenic and immunosuppressive properties which promote tumor growth and progression. Preventing the migration of macrophages into hypoxic tumor regions hinders angiogenesis and restores the tumor-suppressive properties of these immune cells. We have recently uncover...

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Detalles Bibliográficos
Autores principales: Casazza, Andrea, Mazzone, Massimiliano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4008455/
https://www.ncbi.nlm.nih.gov/pubmed/24800172
http://dx.doi.org/10.4161/onci.27872
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author Casazza, Andrea
Mazzone, Massimiliano
author_facet Casazza, Andrea
Mazzone, Massimiliano
author_sort Casazza, Andrea
collection PubMed
description Hypoxia confers to macrophages angiogenic and immunosuppressive properties which promote tumor growth and progression. Preventing the migration of macrophages into hypoxic tumor regions hinders angiogenesis and restores the tumor-suppressive properties of these immune cells. We have recently uncovered a neuropilin 1- and semaphorin 3A-dependent signaling pathway that defines the repositioning of macrophages to hypoxic tumor niches, a discovery that generates new options for the development of complementary anticancer treatments.
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spelling pubmed-40084552015-02-14 Altering the intratumoral localization of macrophages to inhibit cancer progression Casazza, Andrea Mazzone, Massimiliano Oncoimmunology Author's View Hypoxia confers to macrophages angiogenic and immunosuppressive properties which promote tumor growth and progression. Preventing the migration of macrophages into hypoxic tumor regions hinders angiogenesis and restores the tumor-suppressive properties of these immune cells. We have recently uncovered a neuropilin 1- and semaphorin 3A-dependent signaling pathway that defines the repositioning of macrophages to hypoxic tumor niches, a discovery that generates new options for the development of complementary anticancer treatments. Landes Bioscience 2014-02-14 /pmc/articles/PMC4008455/ /pubmed/24800172 http://dx.doi.org/10.4161/onci.27872 Text en Copyright © 2014 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Casazza, Andrea
Mazzone, Massimiliano
Altering the intratumoral localization of macrophages to inhibit cancer progression
title Altering the intratumoral localization of macrophages to inhibit cancer progression
title_full Altering the intratumoral localization of macrophages to inhibit cancer progression
title_fullStr Altering the intratumoral localization of macrophages to inhibit cancer progression
title_full_unstemmed Altering the intratumoral localization of macrophages to inhibit cancer progression
title_short Altering the intratumoral localization of macrophages to inhibit cancer progression
title_sort altering the intratumoral localization of macrophages to inhibit cancer progression
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4008455/
https://www.ncbi.nlm.nih.gov/pubmed/24800172
http://dx.doi.org/10.4161/onci.27872
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