The Chemokine Fractalkine Can Activate Integrins without CX3CR1 through Direct Binding to a Ligand-Binding Site Distinct from the Classical RGD-Binding Site

The chemokine domain of fractalkine (FKN-CD) binds to the classical RGD-binding site of αvβ3 and that the resulting ternary complex formation (integrin-FKN-CX3CR1) is critical for CX3CR1 signaling and FKN-induced integrin activation. However, only certain cell types express CX3CR1. Here we studied i...

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Detalles Bibliográficos
Autores principales: Fujita, Masaaki, Takada, Yoko K., Takada, Yoshikazu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4008574/
https://www.ncbi.nlm.nih.gov/pubmed/24789099
http://dx.doi.org/10.1371/journal.pone.0096372

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4008574/
https://www.ncbi.nlm.nih.gov/pubmed/24789099
http://dx.doi.org/10.1371/journal.pone.0096372

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