Cargando…

An In silico Based Comparison of Drug Interactions in Wild and Mutant Human β-tubulin through Docking Studies

BACKGROUND: Tubulin protein being the fundamental unit of microtubules is actively involved in cell division thus making them a potential anti-cancer drug target. In spite of many reported drugs against tubulin, few of them have started developing resistance in human β-tubulin due to amino acid subs...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chellasamy, Selvaakumar, Mohammed, Sudheer M. M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Avicenna Research Institute 2014
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4009099/ https://www.ncbi.nlm.nih.gov/pubmed/24834310

Ejemplares similares

Molecular docking and dynamic simulations of benzimidazoles with beta-tubulins
por: Rao, Chennu Maruthi Malya Prasada, et al.
Publicado: (2021)

In Silico Exploration of Microtubule Agent Griseofulvin and Its Derivatives Interactions with Different Human β-Tubulin Isotypes
por: Aris, Parisa, et al.
Publicado: (2023)

Identification of key interactions of benzimidazole resistance-associated amino acid mutations in Ascaris β-tubulins by molecular docking simulations
por: Jones, Ben P., et al.
Publicado: (2022)

Molecular Docking and Dynamics Simulation of Protein β-Tubulin and Antifungal Cyclic Lipopeptides
por: Cob-Calan, Nubia Noemi, et al.
Publicado: (2019)

In-silico Investigation of Tubulin Binding Modes of a Series of Novel Antiproliferative Spiroisoxazoline Compounds Using Docking Studies
por: Abolhasani, Hoda, et al.
Publicado: (2015)

Relationship of actin and tubulin distribution to bud growth in wild- type and morphogenetic-mutant Saccharomyces cerevisiae
Publicado: (1984)

Docking and molecular dynamics studies of human ezrin protein with a modelled SARS-CoV-2 endodomain and their interaction with potential invasion inhibitors
por: Chellasamy, Selvaa Kumar, et al.
Publicado: (2022)

In Silico Exploration of Novel Tubulin Inhibitors: A Combination of Docking and Molecular Dynamics Simulations, Pharmacophore Modeling, and Virtual Screening
por: Hadizadeh, Farzin, et al.
Publicado: (2022)

In silico analysis of drug resistance in wild type and mutant HIV-1 subtype d protease
por: Munusami, Punnagai, et al.
Publicado: (2014)

In silico Investigations of the Mode of Action of Novel Colchicine Derivatives Targeting β-Tubulin Isotypes: A Search for a Selective and Specific β-III Tubulin Ligand
por: Pallante, Lorenzo, et al.
Publicado: (2020)

Modeling the Colchicum autumnale Tubulin and a Comparison of Its Interaction with Colchicine to Human Tubulin
por: Spasevska, Ivana, et al.
Publicado: (2017)

Identification of Novel β-Tubulin Inhibitors Using a Combined In Silico/In Vitro Approach
por: Horgan, Mark James, et al.
Publicado: (2023)

Photodegradation and In Silico Molecular Docking Study of a Diuretic Drug: Clopamide
por: Gupta, Anamika, et al.
Publicado: (2022)

Tubulin isotype regulation maintains asymmetric requirement for α-tubulin over β-tubulin
por: Wethekam, Linnea C., et al.
Publicado: (2023)

Molecular Docking of Cryptoconcatones to α-Tubulin and Related Pironetin Analogues
por: Vergoten, Gérard, et al.
Publicado: (2023)

Identification of Potential Lead Molecules for Zika Envelope Protein from In Silico Perspective
por: Chellasamy, Selvaa Kumar, et al.
Publicado: (2019)

Homology Modeling, Molecular Docking, Molecular Dynamic Simulation, and Drug-Likeness of the Modified Alpha-Mangostin against the β-Tubulin Protein of Acanthamoeba Keratitis
por: Ongtanasup, Tassanee, et al.
Publicado: (2022)

Centaurin-α(2) Interacts with β-Tubulin and Stabilizes Microtubules
por: Zuccotti, Paola, et al.
Publicado: (2012)

In Silico Conformation of the Drug Colchicine into Tubulin Models and Acute Phytotoxic Activity on Cucumis sativus Radicles
por: Peña-Morán, Omar Aristeo, et al.
Publicado: (2022)

A Direct Interaction between Leucine-rich Repeat Kinase 2 and Specific β-Tubulin Isoforms Regulates Tubulin Acetylation
por: Law, Bernard M. H., et al.
Publicado: (2014)

Sailing to and Docking at the Immune Synapse: Role of Tubulin Dynamics and Molecular Motors
por: Martín-Cófreces, Noa Beatriz, et al.
Publicado: (2018)

Effect of Rabbit Epididymal Antimicrobial Peptide, REHbβP, on LPS-Induced Proinflammatory Cytokine Responses in Human Vaginal Cells In Vitro
por: Reddy, K. V. R., et al.
Publicado: (2012)

Understanding the Basis of Drug Resistance of the Mutants of αβ-Tubulin Dimer via Molecular Dynamics Simulations
por: Natarajan, Kathiresan, et al.
Publicado: (2012)

Molecular Docking Studies of Marine Diterpenes as Inhibitors of Wild-Type and Mutants HIV-1 Reverse Transcriptase
por: Miceli, Leonardo A., et al.
Publicado: (2013)

Structural Basis and Mechanism for Vindoline Dimers Interacting with α,β-Tubulin
por: Zhang, Zhengqiong, et al.
Publicado: (2019)

Design, synthesis and molecular docking of novel diarylcyclohexenone and diarylindazole derivatives as tubulin polymerization inhibitors
por: Ahmed, Riham I., et al.
Publicado: (2016)

The Roles of β-Tubulin Mutations and Isotype Expression in Acquired Drug Resistance
por: Huzil, J. Torin, et al.
Publicado: (2007)

Target Based Designing of Anthracenone Derivatives as Tubulin Polymerization Inhibiting Agents: 3D QSAR and Docking Approach
por: Samad, Abdul, et al.
Publicado: (2014)

Inactivation of wild-type p53 by a dominant negative mutant renders MCF-7 cells resistant to tubulin-binding agent cytotoxicity
por: Galmarini, C M, et al.
Publicado: (2001)

γ-Tubulin–γ-Tubulin Interactions as the Basis for the Formation of a Meshwork
por: Rosselló, Catalina Ana, et al.
Publicado: (2018)

Drug Targets for Cell Cycle Dysregulators in Leukemogenesis: In Silico Docking Studies
por: Jayaraman, Archana, et al.
Publicado: (2014)

Molecular docking as a popular tool in drug design, an in silico travel
por: de Ruyck, Jerome, et al.
Publicado: (2016)

Synthesis and Molecular Docking Study of New Thiazole Derivatives as Potential Tubulin Polymerization Inhibitors
por: El-Abd, Azhar O., et al.
Publicado: (2022)

Predicting protein-protein interactions with DrugScore(PPI): fully-flexible docking, scoring, and in silico alanine-scanning
por: Krüger, DM, et al.
Publicado: (2011)

Tubulin Bond Energies and Microtubule Biomechanics Determined from Nanoindentation in Silico
por: Kononova, Olga, et al.
Publicado: (2014)

Antisense oligonucleotides to class III β-tubulin sensitize drug-resistant cells to Taxol
por: Kavallaris, M, et al.
Publicado: (1999)

Tubulin structure-based drug design for the development of novel 4β-sulfur-substituted podophyllum tubulin inhibitors with anti-tumor activity
por: Zhao, Wei, et al.
Publicado: (2015)

Specific Targeting of Plant and Apicomplexa Parasite Tubulin through Differential Screening Using In Silico and Assay-Based Approaches
por: Soleilhac, Emmanuelle, et al.
Publicado: (2018)

Structure-based virtual screening, in silico docking, ADME properties prediction and molecular dynamics studies for the identification of potential inhibitors against SARS-CoV-2 M(pro)
por: Mohan, Anbuselvam, et al.
Publicado: (2021)

Induced Dipole–Dipole Interactions Influence the Unfolding Pathways of Wild-Type and Mutant Amyloid β-Peptides
por: Lemkul, Justin A., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_ffkmftjujvhftkj2jv6qps8ck4