PRDM9 binding organizes hotspot nucleosomes and limits Holliday junction migration

In mammals, genetic recombination during meiosis is limited to a set of 1- to 2-kb regions termed hotspots. Their locations are predominantly determined by the zinc finger protein PRDM9, which binds to DNA in hotspots and subsequently uses its SET domain to locally trimethylate histone H3 at lysine...

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Detalles Bibliográficos
Autores principales: Baker, Christopher L., Walker, Michael, Kajita, Shimpei, Petkov, Petko M., Paigen, Kenneth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4009602/
https://www.ncbi.nlm.nih.gov/pubmed/24604780
http://dx.doi.org/10.1101/gr.170167.113

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4009602/
https://www.ncbi.nlm.nih.gov/pubmed/24604780
http://dx.doi.org/10.1101/gr.170167.113

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