Both Cyclophilin Inhibitors and Direct-Acting Antivirals Prevent PKR Activation in HCV-Infected Cells

We and others demonstrated that the contact between NS5A and the host factor CypA is critical for HCV replication. CypI, by disrupting NS5A-CypA complexes, block HCV replication both in vitro and in patients. Since NS5A also binds to PKR, a central component of the IFN response, we investigated the...

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Detalles Bibliográficos
Autores principales: Bobardt, Michael, Chatterji, Udayan, Lim, Precious, Gawlik, Katarzyna, Gallay, Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Open 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4009744/
https://www.ncbi.nlm.nih.gov/pubmed/24799968
http://dx.doi.org/10.2174/1874357901408010001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4009744/
https://www.ncbi.nlm.nih.gov/pubmed/24799968
http://dx.doi.org/10.2174/1874357901408010001

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