In Vitro High Throughput Screening, What Next? Lessons from the Screening for Aurora Kinase Inhibitors

Based on in vitro assays, we performed a High Throughput Screening (HTS) to identify kinase inhibitors among 10,000 small chemical compounds. In this didactic paper, we describe step-by-step the approach to validate the hits as well as the major pitfalls encountered in the development of active mole...

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Detalles Bibliográficos
Autores principales: Hoang, Thi-My-Nhung, Vu, Hong-Lien, Le, Ly-Thuy-Tram, Nguyen, Chi-Hung, Molla, Annie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4009756/
https://www.ncbi.nlm.nih.gov/pubmed/24833340
http://dx.doi.org/10.3390/biology3010167

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4009756/
https://www.ncbi.nlm.nih.gov/pubmed/24833340
http://dx.doi.org/10.3390/biology3010167

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