Broad Specificity Profiling of TALENs Results in Engineered Nucleases With Improved DNA Cleavage Specificity

Although transcription activator-like effector nucleases (TALENs) can be designed to cleave chosen DNA sequences, TALENs have been shown to have activity against related off-target sequences. To better understand TALEN specificity and engineer TALENs with improved specificity, we profiled 30 unique...

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Detalles Bibliográficos
Autores principales: Guilinger, John P., Pattanayak, Vikram, Reyon, Deepak, Tsai, Shengdar Q., Sander, Jeffry D., Joung, J. Keith, Liu, David R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010127/
https://www.ncbi.nlm.nih.gov/pubmed/24531420
http://dx.doi.org/10.1038/nmeth.2845

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010127/
https://www.ncbi.nlm.nih.gov/pubmed/24531420
http://dx.doi.org/10.1038/nmeth.2845

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