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Broad Specificity Profiling of TALENs Results in Engineered Nucleases With Improved DNA Cleavage Specificity

Although transcription activator-like effector nucleases (TALENs) can be designed to cleave chosen DNA sequences, TALENs have been shown to have activity against related off-target sequences. To better understand TALEN specificity and engineer TALENs with improved specificity, we profiled 30 unique...

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Detalles Bibliográficos
Autores principales:	Guilinger, John P., Pattanayak, Vikram, Reyon, Deepak, Tsai, Shengdar Q., Sander, Jeffry D., Joung, J. Keith, Liu, David R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010127/ https://www.ncbi.nlm.nih.gov/pubmed/24531420 http://dx.doi.org/10.1038/nmeth.2845

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