Mammalian TBX1 Preferentially Binds and Regulates Downstream Targets Via a Tandem T-site Repeat

Haploinsufficiency or mutation of TBX1 is largely responsible for the etiology of physical malformations in individuals with velo-cardio-facial/DiGeorge syndrome (VCFS/DGS/22q11.2 deletion syndrome). TBX1 encodes a transcription factor protein that contains an evolutionarily conserved DNA binding do...

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Detalles Bibliográficos
Autores principales: Castellanos, Raquel, Xie, Qing, Zheng, Deyou, Cvekl, Ales, Morrow, Bernice E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010391/
https://www.ncbi.nlm.nih.gov/pubmed/24797903
http://dx.doi.org/10.1371/journal.pone.0095151

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010391/
https://www.ncbi.nlm.nih.gov/pubmed/24797903
http://dx.doi.org/10.1371/journal.pone.0095151

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