Targeting Staphylococcus aureus Quorum Sensing with Nonpeptidic Small Molecule Inhibitors

[Image: see text] A series of 3-oxo-C(12)-HSL, tetramic acid, and tetronic acid analogues were synthesized to gain insights into the structural requirements for quorum sensing inhibition in Staphylococcus aureus. Compounds active against agr were noncompetitive inhibitors of the autoinducing peptide...

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Detalles Bibliográficos
Autores principales: Murray, Ewan J., Crowley, Rebecca C., Truman, Alex, Clarke, Simon R., Cottam, James A., Jadhav, Gopal P., Steele, Victoria R., O’Shea, Paul, Lindholm, Catharina, Cockayne, Alan, Chhabra, Siri Ram, Chan, Weng C., Williams, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010551/
https://www.ncbi.nlm.nih.gov/pubmed/24592914
http://dx.doi.org/10.1021/jm500215s

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010551/
https://www.ncbi.nlm.nih.gov/pubmed/24592914
http://dx.doi.org/10.1021/jm500215s

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