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β-cell dedifferentiation in diabetes is important, but what is it?

This commentary discusses the concept of β-cell dedifferentiation in diabetes, which is important but not well defined. A broad interpretation is that a state of differentiation has been lost, which means changes in gene expression as well as in structural and functional elements. Thus, a fully matu...

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Detalles Bibliográficos
Autores principales: Weir, Gordon C, Aguayo-Mazzucato, Cristina, Bonner-Weir, Susan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010577/
https://www.ncbi.nlm.nih.gov/pubmed/24356710
http://dx.doi.org/10.4161/isl.27494