Cargando…

β-cell dedifferentiation in diabetes is important, but what is it?

This commentary discusses the concept of β-cell dedifferentiation in diabetes, which is important but not well defined. A broad interpretation is that a state of differentiation has been lost, which means changes in gene expression as well as in structural and functional elements. Thus, a fully matu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Weir, Gordon C, Aguayo-Mazzucato, Cristina, Bonner-Weir, Susan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Landes Bioscience 2013
Materias:	Commentary
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010577/ https://www.ncbi.nlm.nih.gov/pubmed/24356710 http://dx.doi.org/10.4161/isl.27494

Ejemplares similares

Sleeping Islets and the Relationship Between β-Cell Mass and Function
por: Weir, Gordon C., et al.
Publicado: (2011)

Dynamic development of the pancreas from birth to adulthood
por: Bonner-Weir, Susan, et al.
Publicado: (2016)

Islet β cell mass in diabetes and how it relates to function, birth, and death
por: Weir, Gordon C, et al.
Publicado: (2013)

Glucose Driven Changes in Beta Cell Identity Are Important for Function and Possibly Autoimmune Vulnerability during the Progression of Type 1 Diabetes
por: Weir, Gordon C., et al.
Publicado: (2017)

PDX1 in Ducts Is Not Required for Postnatal Formation of β-Cells but Is Necessary for Their Subsequent Maturation
por: Guo, Lili, et al.
Publicado: (2013)

Conflicting Views About Interactions Between Pancreatic α-Cells and β-Cells
por: Weir, Gordon C., et al.
Publicado: (2023)

Thyroid Hormone Promotes Postnatal Rat Pancreatic β-Cell Development and Glucose-Responsive Insulin Secretion Through MAFA
por: Aguayo-Mazzucato, Cristina, et al.
Publicado: (2013)

Induction of remission in diabetes by lowering blood glucose
por: Weir, Gordon C., et al.
Publicado: (2023)

Stem cell approaches for diabetes: towards beta cell replacement
por: Weir, Gordon C, et al.
Publicado: (2011)

Reduced Ki67 Staining in the Postmortem State Calls Into Question Past Conclusions About the Lack of Turnover of Adult Human β-Cells
por: Sullivan, Brooke A., et al.
Publicado: (2015)

β-Cell Growth and Regeneration: Replication Is Only Part of the Story
por: Bonner-Weir, Susan, et al.
Publicado: (2010)

Multiple secondary outcome analyses: precise interpretation is important
por: Parker, Richard A., et al.
Publicado: (2022)

β-cell senescence in type 2 diabetes
por: Aguayo-Mazzucato, Cristina, et al.
Publicado: (2019)

PAHSAs reduce cellular senescence and protect pancreatic beta cells from metabolic stress through regulation of Mdm2/p53
por: Rubin de Celis, Maria F., et al.
Publicado: (2022)

Response to Comment on: Keenan et al. (2010) Residual Insulin Production and Pancreatic β-Cell Turnover After 50 Years of Diabetes: Joslin Medalist Study. Diabetes 2010;59:2846–2853
por: Keenan, Hillary A., et al.
Publicado: (2010)

Dedifferentiation rescues senescence of progeria cells but only while pluripotent
por: Niedernhofer, Laura J, et al.
Publicado: (2011)

Gene Expression Profiles of Beta-Cell Enriched Tissue Obtained by Laser Capture Microdissection from Subjects with Type 2 Diabetes
por: Marselli, Lorella, et al.
Publicado: (2010)

SUN-LB059 A Rare Case Of Hypoglycemia Secondary To Proinsulin-Intermediate Secreting Tumor
por: Zainal, Abir, et al.
Publicado: (2019)

Reversing and modulating cellular senescence in beta cells, a new field of opportunities to treat diabetes
por: Rubin de Celis, Maria F., et al.
Publicado: (2023)

What Is Important?
por: Rankin, John A.
Publicado: (2020)

Pancreatic β-cell senescence in diabetes: mechanisms, markers and therapies
por: Cha, Jeeyeon, et al.
Publicado: (2023)

An Appreciation of Robert Turner
por: O'Rahilly, Stephen, et al.
Publicado: (2008)

Islets in Type 2 Diabetes: In Honor of Dr. Robert C. Turner
por: Bonner-Weir, Susan, et al.
Publicado: (2008)

Type 1 diabetes: what is the role of autoimmunity in β cell death?
por: Donath, Marc Y.
Publicado: (2022)

Beta cell identity changes with mild hyperglycemia: Implications for function, growth, and vulnerability
por: Ebrahimi, Aref G., et al.
Publicado: (2020)

Decoupling dedifferentiation and G(2)/M arrest in kidney fibrosis
por: Humphreys, Benjamin D.
Publicado: (2022)

Through the Narrative Looking Glass: Commentary on “Impact of Electronic Health Records on Information Practices in Mental Health Contexts: Scoping Review”
por: Weir, Charlene
Publicado: (2022)

Why pancreatic islets should be regarded and regulated like organs
por: Weir, G. C., et al.
Publicado: (2021)

Sustained NF-κB Activation and Inhibition in β-Cells Have Minimal Effects on Function and Islet Transplant Outcomes
por: King, Aileen J. F., et al.
Publicado: (2013)

The Role of Inflammation in β-cell Dedifferentiation
por: Nordmann, Thierry M., et al.
Publicado: (2017)

The Polycomb-Dependent Epigenome Controls β Cell Dysfunction, Dedifferentiation, and Diabetes
por: Lu, Tess Tsai-Hsiu, et al.
Publicado: (2018)

Reversing pancreatic β-cell dedifferentiation in the treatment of type 2 diabetes
por: Son, Jinsook, et al.
Publicado: (2023)

Quantitative analysis of cell composition and purity of human pancreatic islet preparations
por: Pisania, Anna, et al.
Publicado: (2010)

Residual Insulin Production and Pancreatic β-Cell Turnover After 50 Years of Diabetes: Joslin Medalist Study
por: Keenan, Hillary A., et al.
Publicado: (2010)

Genetic Disruption of SOD1 Gene Causes Glucose Intolerance and Impairs β-Cell Function
por: Muscogiuri, Giovanna, et al.
Publicado: (2013)

A Brief Review of the Mechanisms of β-Cell Dedifferentiation in Type 2 Diabetes
por: Khin, Phyu-Phyu, et al.
Publicado: (2021)

Protective Unfolded Protein Response in Human Pancreatic Beta Cells Transplanted into Mice
por: Kennedy, Jeffrey, et al.
Publicado: (2010)

Targeting B-cells Mitigates Autoimmune Diabetes in NOD Mice: What Is Plan B?
por: Smith, Susan H., et al.
Publicado: (2009)

Initiating Antidepressant Medication: What is the Most Important Factor?
por: Kasper, Siegfried
Publicado: (2022)

Targeting β-cell dedifferentiation and transdifferentiation: opportunities and challenges
por: Wang, Wenrui, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_246dft0hpt19mlsacli8l4e1tg