Assessing analytical methods to monitor isoAsp formation in monoclonal antibodies

A ubiquitous post-translational modification observed in proteins is isomerization of aspartic acid to isoaspartic acid (isoAsp). This non-enzymatic post-translational modification occurs spontaneously in proteins and plays a role in aging, autoimmune response, cancer, neurodegeneration, and other d...

Descripción completa

Detalles Bibliográficos
Autores principales: Eakin, Catherine M., Miller, Amanda, Kerr, Jennifer, Kung, James, Wallace, Alison
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010776/
https://www.ncbi.nlm.nih.gov/pubmed/24808864
http://dx.doi.org/10.3389/fphar.2014.00087

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010776/
https://www.ncbi.nlm.nih.gov/pubmed/24808864
http://dx.doi.org/10.3389/fphar.2014.00087

Ejemplares similares