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Assessing analytical methods to monitor isoAsp formation in monoclonal antibodies

A ubiquitous post-translational modification observed in proteins is isomerization of aspartic acid to isoaspartic acid (isoAsp). This non-enzymatic post-translational modification occurs spontaneously in proteins and plays a role in aging, autoimmune response, cancer, neurodegeneration, and other d...

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Detalles Bibliográficos
Autores principales:	Eakin, Catherine M., Miller, Amanda, Kerr, Jennifer, Kung, James, Wallace, Alison
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2014
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010776/ https://www.ncbi.nlm.nih.gov/pubmed/24808864 http://dx.doi.org/10.3389/fphar.2014.00087

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