Elucidation of the enigmatic IgD class-switch recombination via germline deletion of the IgH 3′ regulatory region

Classical class-switch recombination (cCSR) substitutes the C(μ) gene with C(γ), C(ε), or C(α), thereby generating IgG, IgE, or IgA classes, respectively. This activation-induced deaminase (AID)–driven process is controlled by the IgH 3′ regulatory region (3′RR). Regulation of rare IgD CSR events ha...

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Detalles Bibliográficos
Autores principales: Rouaud, Pauline, Saintamand, Alexis, Saad, Faten, Carrion, Claire, Lecardeur, Sandrine, Cogné, Michel, Denizot, Yves
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010897/
https://www.ncbi.nlm.nih.gov/pubmed/24752300
http://dx.doi.org/10.1084/jem.20131385

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010897/
https://www.ncbi.nlm.nih.gov/pubmed/24752300
http://dx.doi.org/10.1084/jem.20131385

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