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Elucidation of the enigmatic IgD class-switch recombination via germline deletion of the IgH 3′ regulatory region
Classical class-switch recombination (cCSR) substitutes the C(μ) gene with C(γ), C(ε), or C(α), thereby generating IgG, IgE, or IgA classes, respectively. This activation-induced deaminase (AID)–driven process is controlled by the IgH 3′ regulatory region (3′RR). Regulation of rare IgD CSR events ha...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010897/ https://www.ncbi.nlm.nih.gov/pubmed/24752300 http://dx.doi.org/10.1084/jem.20131385 |