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Type I interferons directly inhibit regulatory T cells to allow optimal antiviral T cell responses during acute LCMV infection

Regulatory T (T reg) cells play an essential role in preventing autoimmunity but can also impair clearance of foreign pathogens. Paradoxically, signals known to promote T reg cell function are abundant during infection and could inappropriately enhance T reg cell activity. How T reg cell function is...

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Detalles Bibliográficos
Autores principales: Srivastava, Shivani, Koch, Meghan A., Pepper, Marion, Campbell, Daniel J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010906/
https://www.ncbi.nlm.nih.gov/pubmed/24711580
http://dx.doi.org/10.1084/jem.20131556