Enhancement of an anti-tumor immune response by transient blockade of central T cell tolerance

Thymic central tolerance is a critical process that prevents autoimmunity but also presents a challenge to the generation of anti-tumor immune responses. Medullary thymic epithelial cells (mTECs) eliminate self-reactive T cells by displaying a diverse repertoire of tissue-specific antigens (TSAs) th...

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Detalles Bibliográficos
Autores principales: Khan, Imran S., Mouchess, Maria L., Zhu, Meng-Lei, Conley, Bridget, Fasano, Kayla J., Hou, Yafei, Fong, Lawrence, Su, Maureen A., Anderson, Mark S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2014
Materias:
Brief Definitive Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010907/
https://www.ncbi.nlm.nih.gov/pubmed/24752296
http://dx.doi.org/10.1084/jem.20131889

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010907/
https://www.ncbi.nlm.nih.gov/pubmed/24752296
http://dx.doi.org/10.1084/jem.20131889

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