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de novo Synthesis of a Bacterial Toxin/Antitoxin System

The prevalence of toxin/antitoxin (TA) systems in almost all genomes suggests they evolve rapidly. Here we show that an antitoxin from a type V system (GhoS, an endoribonuclease specific for the mRNA of the toxin GhoT) can be converted into a novel toxin (ArT) simply by adding two mutations. In cont...

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Detalles Bibliográficos
Autores principales: Soo, Valerie W. C., Cheng, Hsin-Yao, Kwan, Brian W., Wood, Thomas K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010927/
https://www.ncbi.nlm.nih.gov/pubmed/24797297
http://dx.doi.org/10.1038/srep04807