The Biology of Autoimmune Response in the Scurfy Mice that Lack the CD4(+)Foxp3(+) Regulatory T-Cells

Due to a mutation in the Foxp3 transcription factor, Scurfy mice lack regulatory T-cells that maintain self-tolerance of the immune system. They develop multi-organ inflammation (MOI) and die around four weeks old. The affected organs are skin, tail, lungs and liver. In humans, endocrine and gastroi...

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Detalles Bibliográficos
Autores principales: Ju, Shyr-Te, Sharma, Rahul, Gaskin, Felicia, Kung, John T., Fu, Shu Man
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4011033/
https://www.ncbi.nlm.nih.gov/pubmed/24832045
http://dx.doi.org/10.3390/biology1010018

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4011033/
https://www.ncbi.nlm.nih.gov/pubmed/24832045
http://dx.doi.org/10.3390/biology1010018

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