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The Biology of Autoimmune Response in the Scurfy Mice that Lack the CD4(+)Foxp3(+) Regulatory T-Cells
Due to a mutation in the Foxp3 transcription factor, Scurfy mice lack regulatory T-cells that maintain self-tolerance of the immune system. They develop multi-organ inflammation (MOI) and die around four weeks old. The affected organs are skin, tail, lungs and liver. In humans, endocrine and gastroi...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4011033/ https://www.ncbi.nlm.nih.gov/pubmed/24832045 http://dx.doi.org/10.3390/biology1010018 |