Making a Short Story Long: Regulation of P-TEFb and HIV-1 Transcriptional Elongation in CD4(+) T Lymphocytes and Macrophages

Productive transcription of the integrated HIV-1 provirus is restricted by cellular factors that inhibit RNA polymerase II elongation. The viral Tat protein overcomes this by recruiting a general elongation factor, P-TEFb, to the TAR RNA element that forms at the 5’ end of nascent viral transcripts....

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Detalles Bibliográficos
Autores principales: Ramakrishnan, Rajesh, Chiang, Karen, Liu, Hongbing, Budhiraja, Sona, Donahue, Hart, Rice, Andrew P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4011037/
https://www.ncbi.nlm.nih.gov/pubmed/24832049
http://dx.doi.org/10.3390/biology1010094

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4011037/
https://www.ncbi.nlm.nih.gov/pubmed/24832049
http://dx.doi.org/10.3390/biology1010094

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