Powers of the Likelihood Ratio Test and the Correlation Test Using Empirical Bayes Estimates for Various Shrinkages in Population Pharmacokinetics

We compared the powers of the likelihood ratio test (LRT) and the Pearson correlation test (CT) from empirical Bayes estimates (EBEs) for various designs and shrinkages in the context of nonlinear mixed-effect modeling. Clinical trial simulation was performed with a simple pharmacokinetic model with...

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Detalles Bibliográficos
Autores principales: Combes, F P, Retout, S, Frey, N, Mentré, F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4011164/
https://www.ncbi.nlm.nih.gov/pubmed/24717242
http://dx.doi.org/10.1038/psp.2014.5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4011164/
https://www.ncbi.nlm.nih.gov/pubmed/24717242
http://dx.doi.org/10.1038/psp.2014.5

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