Trisubstituted 2-Trifluoromethyl Pyrrolidines via Catalytic Asymmetric Michael Addition/Reductive Cyclization

[Image: see text] The stereoselective synthesis of trisubstituted 2-trifluoromethyl pyrrolidines by asymmetric Michael addition/hydrogenative cyclization is described. The direct organocatalytic addition of 1,1,1-trifluoromethylketones to nitroolefins proceeds under mild reaction conditions and low...

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Detalles Bibliográficos
Autores principales: Corbett, Michael T., Xu, Qihai, Johnson, Jeffrey S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4011570/
https://www.ncbi.nlm.nih.gov/pubmed/24746344
http://dx.doi.org/10.1021/ol500679w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4011570/
https://www.ncbi.nlm.nih.gov/pubmed/24746344
http://dx.doi.org/10.1021/ol500679w

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