HCMV glycoprotein B is expressed in primary glioblastomas and enhances growth and invasiveness via PDGFR-alpha activation

Our laboratory first demonstrated that human cytomegalovirus (HCMV) is associated with the most deadly form of primary brain tumor, glioblastoma (GBM). We showed that HCMV glycoprotein B (gB) mediates viral cellular entry via the receptor tyrosine kinase PDGFR-alpha (PDGFRα), resulting in activation...

Descripción completa

Detalles Bibliográficos
Autores principales: Cobbs, Charles, Khan, Sabeena, Matlaf, Lisa, McAllister, Sean, Zider, Alex, Yount, Garret, Rahlin, Kenneth, Harkins, Lualhati, Bezrookove, Vladimir, Singer, Eric, Soroceanu, Liliana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4011586/
https://www.ncbi.nlm.nih.gov/pubmed/24658280

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4011586/
https://www.ncbi.nlm.nih.gov/pubmed/24658280

Ejemplares similares