Inhibiting Heat Shock Factor 1 in Human Cancer Cells with a Potent RNA Aptamer

Heat shock factor 1 (HSF1) is a master regulator that coordinates chaperone protein expression to enhance cellular survival in the face of heat stress. In cancer cells, HSF1 drives a transcriptional program distinct from heat shock to promote metastasis and cell survival. Its strong association with...

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Detalles Bibliográficos
Autores principales: Salamanca, H. Hans, Antonyak, Marc A., Cerione, Richard A., Shi, Hua, Lis, John T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4011729/
https://www.ncbi.nlm.nih.gov/pubmed/24800749
http://dx.doi.org/10.1371/journal.pone.0096330

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4011729/
https://www.ncbi.nlm.nih.gov/pubmed/24800749
http://dx.doi.org/10.1371/journal.pone.0096330

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