Fenofibrate Improves Renal Lipotoxicity through Activation of AMPK-PGC-1α in db/db Mice

Peroxisome proliferator-activated receptor (PPAR)-α, a lipid-sensing transcriptional factor, serves an important role in lipotoxicity. We evaluated whether fenofibrate has a renoprotective effect by ameliorating lipotoxicity in the kidney. Eight-week-old male C57BLKS/J db/m control and db/db mice, d...

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Detalles Bibliográficos
Autores principales: Hong, Yu Ah, Lim, Ji Hee, Kim, Min Young, Kim, Tae Woo, Kim, Yaeni, Yang, Keun Suk, Park, Hoon Suk, Choi, Sun Ryoung, Chung, Sungjin, Kim, Hyung Wook, Kim, Hye Won, Choi, Bum Soon, Chang, Yoon Sik, Park, Cheol Whee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4011795/
https://www.ncbi.nlm.nih.gov/pubmed/24801481
http://dx.doi.org/10.1371/journal.pone.0096147

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4011795/
https://www.ncbi.nlm.nih.gov/pubmed/24801481
http://dx.doi.org/10.1371/journal.pone.0096147

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