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Apurinic/Apyrimidinic Endonucleases of Mycobacterium tuberculosis Protect against DNA Damage but Are Dispensable for the Growth of the Pathogen in Guinea Pigs

In host cells, Mycobacterium tuberculosis encounters an array of reactive molecules capable of damaging its genome. Non-bulky DNA lesions are the most common damages produced on the exposure of the pathogen to reactive species and base excision repair (BER) pathway is involved in the repair of such...

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Detalles Bibliográficos
Autores principales: Puri, Rupangi Verma, Reddy, P. Vineel, Tyagi, Anil K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4011885/
https://www.ncbi.nlm.nih.gov/pubmed/24800740
http://dx.doi.org/10.1371/journal.pone.0092035