Red colored IgG4 caused by vitamin B12 from cell culture media combined with disulfide reduction at harvest

While many antibody therapeutics are formulated at low concentration (~10–20 mg/mL) for intravenous administration, high concentration (> 100 mg/mL) formulations may be required for subcutaneous delivery in certain clinical indications. For such high concentration formulations, product color is m...

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Detalles Bibliográficos
Autores principales: Derfus, Gayle E, Dizon-Maspat, Jemelle, Broddrick, Jared T, Velayo, Arleene C, Toschi, Josh D, Santuray, Rodell T, Hsu, Stephen K, Winter, Charles M, Krishnan, Rajesh, Amanullah, Ashraf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4011912/
https://www.ncbi.nlm.nih.gov/pubmed/24552690
http://dx.doi.org/10.4161/mabs.28257

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4011912/
https://www.ncbi.nlm.nih.gov/pubmed/24552690
http://dx.doi.org/10.4161/mabs.28257

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