Molecular Imaging of Cell Death in Tumors. Increasing Annexin A5 Size Reduces Contribution of Phosphatidylserine-Targeting Function to Tumor Uptake

OBJECTIVE: Annexin A5 is a phosphatidylserine binding protein that binds dying cells in vivo. Annexin A5 is a potential molecular imaging agent to determine efficacy of anti-cancer therapy in patients. Its rapid clearance from circulation limits tumor uptake and, hence, its sensitivity. The aim of t...

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Detalles Bibliográficos
Autores principales: Ungethüm, Lisette, Chatrou, Martijn, Kusters, Dennis, Schurgers, Leon, Reutelingsperger, Chris P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4011958/
https://www.ncbi.nlm.nih.gov/pubmed/24801051
http://dx.doi.org/10.1371/journal.pone.0096749

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4011958/
https://www.ncbi.nlm.nih.gov/pubmed/24801051
http://dx.doi.org/10.1371/journal.pone.0096749

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