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Inhibition of Cell Proliferation and Migration by miR-509-3p That Targets CDK2, Rac1, and PIK3C2A

CDK2 is a key regulator of cell cycle progression. In this study, we screened for miRNAs targeting CDK2 using a luciferase-3′-untranslated region reporter assay. Among 11 hit miRNAs, miR-509-3p reduced CDK2 protein levels and significantly inhibited cancer cell growth. Microarray, Western blotting,...

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Detalles Bibliográficos
Autores principales: Yoon, Sena, Han, Eunji, Choi, Young-Chul, Kee, Honghwan, Jeong, Yongsu, Yoon, Jaeseung, Baek, Kwanghee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Molecular and Cellular Biology 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012080/
https://www.ncbi.nlm.nih.gov/pubmed/24802056
http://dx.doi.org/10.14348/molcells.2014.2360