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Effect of the Brugada syndrome mutation A39V on calmodulin regulation of Cav1.2 channels

BACKGROUND: The L-type calcium channel Cav1.2 is important for brain and heart function. The ubiquitous calcium sensing protein calmodulin (CaM) regulates calcium dependent gating of Cav1.2 channels by reducing calcium influx, a process known as calcium-dependent inactivation (CDI). Dissecting the c...

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Detalles Bibliográficos
Autores principales:	Simms, Brett A, Souza, Ivana Assis, Zamponi, Gerald W
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012176/ https://www.ncbi.nlm.nih.gov/pubmed/24775099 http://dx.doi.org/10.1186/1756-6606-7-34

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