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Mice with altered BDNF signaling as models for mood disorders and antidepressant effects

Brain-derived neurotrophic factor (BDNF) and its receptor tyrosine kinase TrkB support neuronal survival during development and promote connectivity and plasticity in the adult brain. Decreased BDNF signaling is associated with the pathophysiology of depression and the mechanisms underlying the acti...

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Detalles Bibliográficos
Autores principales: Lindholm, Jesse S. O., Castrén, Eero
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012208/
https://www.ncbi.nlm.nih.gov/pubmed/24817844
http://dx.doi.org/10.3389/fnbeh.2014.00143
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author Lindholm, Jesse S. O.
Castrén, Eero
author_facet Lindholm, Jesse S. O.
Castrén, Eero
author_sort Lindholm, Jesse S. O.
collection PubMed
description Brain-derived neurotrophic factor (BDNF) and its receptor tyrosine kinase TrkB support neuronal survival during development and promote connectivity and plasticity in the adult brain. Decreased BDNF signaling is associated with the pathophysiology of depression and the mechanisms underlying the actions of antidepressant drugs (AD). Several transgenic mouse models with decreases or increases in the amount of BDNF or the activity of TrkB signaling have been created. This review summarizes the studies where various mouse models with increased or decreased BDNF levels or TrkB signaling were used to evaluate the role of BDNF signaling in depression-like behavior. Although a large number of models have been employed and several studies have been published, no clear-cut connections between BDNF levels or signaling and depression-like behavior in mice have emerged. However, it is clear that BDNF plays a critical role in the mechanisms underlying the actions of AD.
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spelling pubmed-40122082014-05-09 Mice with altered BDNF signaling as models for mood disorders and antidepressant effects Lindholm, Jesse S. O. Castrén, Eero Front Behav Neurosci Neuroscience Brain-derived neurotrophic factor (BDNF) and its receptor tyrosine kinase TrkB support neuronal survival during development and promote connectivity and plasticity in the adult brain. Decreased BDNF signaling is associated with the pathophysiology of depression and the mechanisms underlying the actions of antidepressant drugs (AD). Several transgenic mouse models with decreases or increases in the amount of BDNF or the activity of TrkB signaling have been created. This review summarizes the studies where various mouse models with increased or decreased BDNF levels or TrkB signaling were used to evaluate the role of BDNF signaling in depression-like behavior. Although a large number of models have been employed and several studies have been published, no clear-cut connections between BDNF levels or signaling and depression-like behavior in mice have emerged. However, it is clear that BDNF plays a critical role in the mechanisms underlying the actions of AD. Frontiers Media S.A. 2014-04-30 /pmc/articles/PMC4012208/ /pubmed/24817844 http://dx.doi.org/10.3389/fnbeh.2014.00143 Text en Copyright © 2014 Lindholm and Castrén. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Lindholm, Jesse S. O.
Castrén, Eero
Mice with altered BDNF signaling as models for mood disorders and antidepressant effects
title Mice with altered BDNF signaling as models for mood disorders and antidepressant effects
title_full Mice with altered BDNF signaling as models for mood disorders and antidepressant effects
title_fullStr Mice with altered BDNF signaling as models for mood disorders and antidepressant effects
title_full_unstemmed Mice with altered BDNF signaling as models for mood disorders and antidepressant effects
title_short Mice with altered BDNF signaling as models for mood disorders and antidepressant effects
title_sort mice with altered bdnf signaling as models for mood disorders and antidepressant effects
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012208/
https://www.ncbi.nlm.nih.gov/pubmed/24817844
http://dx.doi.org/10.3389/fnbeh.2014.00143
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