Apogossypolone targets mitochondria and light enhances its anticancer activity by stimulating generation of singlet oxygen and reactive oxygen species

Apogossypolone (ApoG2), a novel derivative of gossypol, has been shown to be a potent inhibitor of antiapoptotic Bcl-2 family proteins and to have antitumor activity in multiple types of cancer cells. Recent reports suggest that gossypol stimulates the generation of cellular reactive oxygen species...

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Detalles Bibliográficos
Autores principales: Hu, Zhe-Yu, Wang, Jing, Cheng, Gang, Zhu, Xiao-Feng, Huang, Peng, Yang, Dajun, Zeng, Yi-Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sun Yat-sen University Cancer Center 2011
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012262/
https://www.ncbi.nlm.nih.gov/pubmed/21192843
http://dx.doi.org/10.5732/cjc.010.10295

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012262/
https://www.ncbi.nlm.nih.gov/pubmed/21192843
http://dx.doi.org/10.5732/cjc.010.10295

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