Effect of chronic antipsychotic treatment on striatal phosphodiesterase 10A levels: a [(11)C]MP-10 PET rodent imaging study with ex vivo confirmation

A number of phosphodiesterase 10A (PDE10) inhibitors are about to undergo clinical evaluation for their efficacy in treating schizophrenia. As phosphodiesterases are in the same signalling pathway as dopamine D(2) receptors, it is possible that prior antipsychotic treatment could influence these enz...

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Detalles Bibliográficos
Autores principales: Natesan, S, Ashworth, S, Nielsen, J, Tang, S-P, Salinas, C, Kealey, S, Lauridsen, J B, Stensbøl, T B, Gunn, R N, Rabiner, E A, Kapur, S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012281/
https://www.ncbi.nlm.nih.gov/pubmed/24690597
http://dx.doi.org/10.1038/tp.2014.17

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012281/
https://www.ncbi.nlm.nih.gov/pubmed/24690597
http://dx.doi.org/10.1038/tp.2014.17

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