Tau promotes neurodegeneration through global chromatin relaxation

The microtubule-associated protein tau is involved in a number of neurodegenerative disorders, including Alzheimer’s disease (AD). Previous studies link oxidative stress and subsequent DNA damage to neuronal death in AD and related tauopathies. Since DNA damage can significantly alter chromatin stru...

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Detalles Bibliográficos
Autores principales: Frost, Bess, Hemberg, Martin, Lewis, Jada, Feany, Mel B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012297/
https://www.ncbi.nlm.nih.gov/pubmed/24464041
http://dx.doi.org/10.1038/nn.3639

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012297/
https://www.ncbi.nlm.nih.gov/pubmed/24464041
http://dx.doi.org/10.1038/nn.3639

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