A Practical Strategy to Discover New Antitumor Compounds by Activating Silent Metabolite Production in Fungi by Diethyl Sulphate Mutagenesis

Many fungal biosynthetic pathways are silent in standard culture conditions, and activation of the silent pathways may enable access to new metabolites with antitumor activities. The aim of the present study was to develop a practical strategy for microbial chemists to access silent metabolites in f...

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Detalles Bibliográficos
Autores principales: Fang, Shi-Ming, Wu, Chang-Jing, Li, Chang-Wei, Cui, Cheng-Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012455/
https://www.ncbi.nlm.nih.gov/pubmed/24681631
http://dx.doi.org/10.3390/md12041788

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012455/
https://www.ncbi.nlm.nih.gov/pubmed/24681631
http://dx.doi.org/10.3390/md12041788

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