Cargando…

The Dimerization Domain in DapE Enzymes Is required for Catalysis

The emergence of antibiotic-resistant bacterial strains underscores the importance of identifying new drug targets and developing new antimicrobial compounds. Lysine and meso-diaminopimelic acid are essential for protein production and bacterial peptidoglycan cell wall remodeling and are synthesized...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nocek, Boguslaw, Starus, Anna, Makowska-Grzyska, Magdalena, Gutierrez, Blanca, Sanchez, Stephen, Jedrzejczak, Robert, Mack, Jamey C., Olsen, Kenneth W., Joachimiak, Andrzej, Holz, Richard C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012986/ https://www.ncbi.nlm.nih.gov/pubmed/24806882 http://dx.doi.org/10.1371/journal.pone.0093593

Ejemplares similares

Indoline-6-Sulfonamide Inhibitors of the Bacterial Enzyme DapE
por: Reidl, Cory T., et al.
Publicado: (2020)

Practical spectrophotometric assay for the dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase, a potential antibiotic target
por: Heath, Tahirah K., et al.
Publicado: (2018)

Selectivity of Inhibition of N-Succinyl-l,l-Diaminopimelic Acid Desuccinylase in Bacteria: The product of dapE-gene Is Not the Target of l-Captopril Antimicrobial Activity
por: Uda, Narasimha Rao, et al.
Publicado: (2011)

Functional Characterization of Four Putative δ(1)-Pyrroline-5-Carboxylate Reductases from Bacillus subtilis
por: Forlani, Giuseppe, et al.
Publicado: (2017)

dAPE: a web server to detect homorepeats and follow their evolution
por: Mier, Pablo, et al.
Publicado: (2017)

Structure of Cryptosporidium IMP dehydrogenase bound to an inhibitor with in vivo antiparasitic activity
por: Kim, Youngchang, et al.
Publicado: (2015)

Structure-Guided, Single-Point Modifications in the Phosphinic Dipeptide Structure Yield Highly Potent and Selective Inhibitors of Neutral Aminopeptidases
por: Vassiliou, Stamatia, et al.
Publicado: (2014)

Why Are Some Enzymes Dimers? Flexibility and Catalysis in Thermotoga maritima Dihydrofolate Reductase
por: Ruiz-Pernía, J. Javier, et al.
Publicado: (2019)

Catalysis with Palladium(I) Dimers
por: Fricke, Christoph, et al.
Publicado: (2020)

Debating DAP12
por: Van Epps, Heather L.
Publicado: (2005)

Conservation of the structure and function of bacterial tryptophan synthases
por: Michalska, Karolina, et al.
Publicado: (2019)

The CRISPR-associated Cas4 protein Pcal_0546 from Pyrobaculum calidifontis contains a [2Fe-2S] cluster: crystal structure and nuclease activity
por: Lemak, Sofia, et al.
Publicado: (2014)

A Novel Cofactor-binding Mode in Bacterial IMP Dehydrogenases Explains Inhibitor Selectivity
por: Makowska-Grzyska, Magdalena, et al.
Publicado: (2015)

615. Daptomycin (DAP) Synergy with β-Lactams in DAP-Resistant (DAP-R) E. faecium (Efm) Is Dependent On PBP5 Sequence and β-Lactam-binding Affinity
por: Khan, Ayesha, et al.
Publicado: (2019)

Enzymic Catalysis
por: Hageman, James
Publicado: (1969)

Dap10 and Dap12 Form Distinct, but Functionally Cooperative, Receptor Complexes in Natural Killer Cells
por: Wu, Jun, et al.
Publicado: (2000)

Genomic Pathways Associated with Daptomycin (DAP) Resistance in DAP-Susceptible Enterococcus faecium Harboring Substitutions in LiaFSR
por: Tran, Truc T, et al.
Publicado: (2017)

Correction to Differential Stabilities and Sequence-Dependent Base Pair Opening Dynamics of Watson–Crick Base Pairs with 5-Hydroxymethylcytosine, 5-Formylcytosine, or 5-Carboxylcytosine
por: Szulik, Marta W., et al.
Publicado: (2015)

Differential Stabilities and Sequence-Dependent Base Pair Opening Dynamics of Watson–Crick Base Pairs with 5-Hydroxymethylcytosine, 5-Formylcytosine, or 5-Carboxylcytosine
por: Szulik, Marta W., et al.
Publicado: (2015)

Synthesis, in Vitro Evaluation and Cocrystal Structure of 4-Oxo-[1]benzopyrano[4,3-c]pyrazole Cryptosporidium parvum Inosine 5′-Monophosphate Dehydrogenase (CpIMPDH) Inhibitors
por: Sun, Zhuming, et al.
Publicado: (2014)

Structural and kinetic insights into stimulation of RppH-dependent RNA degradation by the metabolic enzyme DapF
por: Gao, Ang, et al.
Publicado: (2018)

Enzyme Catalysis To Power Micro/Nanomachines
por: Ma, Xing, et al.
Publicado: (2016)

New Perspectives on Thiamine Catalysis: From Enzymic to Biomimetic Catalysis
por: Stamatis, A., et al.
Publicado: (2007)

Actomyosin fibers DApPLE epithelial apical junctions
por: Manzano, Alejandra R., et al.
Publicado: (2022)

Mycobacterium tuberculosis IMPDH in Complexes with Substrates, Products and Antitubercular Compounds
por: Makowska-Grzyska, Magdalena, et al.
Publicado: (2015)

A Facile Synthesis of Fully Protected meso-Diaminopimelic Acid (DAP) and Its Application to the Preparation of Lipophilic N-Acyl iE-DAP
por: Saito, Yukako, et al.
Publicado: (2013)

Perspectives on Electrostatics and Conformational Motions in Enzyme Catalysis
por: Hanoian, Philip, et al.
Publicado: (2015)

Structural insights into catalysis and dimerization enhanced exonuclease activity of RNase J
por: Zhao, Ye, et al.
Publicado: (2015)

On the Redox Properties of the Dimers of Thiazol-2-ylidenes That Are Relevant for Radical Catalysis
por: Delfau, Ludivine, et al.
Publicado: (2023)

Linking Protein Motion to Enzyme Catalysis
por: Singh, Priyanka, et al.
Publicado: (2015)

Engineering enzyme catalysis: an inverse approach
por: Megarity, Clare F.
Publicado: (2019)

Enzyme Models—From Catalysis to Prodrugs
por: Breijyeh, Zeinab, et al.
Publicado: (2021)

Mapping enzyme catalysis with metabolic biosensing
por: Xu, Linfeng, et al.
Publicado: (2021)

The structure of Medicago truncatula δ(1)-pyrroline-5-carboxylate reductase provides new insights into regulation of proline biosynthesis in plants
por: Ruszkowski, Milosz, et al.
Publicado: (2015)

DAP12 Overexpression Induces Osteopenia and Impaired Early Hematopoiesis
por: Despars, Geneviève, et al.
Publicado: (2013)

The Role of Centrosome Distal Appendage Proteins (DAPs) in Nephronophthisis and Ciliogenesis
por: Mansour, Fatma, et al.
Publicado: (2021)

Loop Dynamics and Enzyme Catalysis in Protein Tyrosine Phosphatases
por: Crean, Rory M., et al.
Publicado: (2021)

Role of TREM1-DAP12 in Renal Inflammation during Obstructive Nephropathy
por: Tammaro, Alessandra, et al.
Publicado: (2013)

Chlamydia trachomatis dapF Encodes a Bifunctional Enzyme Capable of Both d-Glutamate Racemase and Diaminopimelate Epimerase Activities
por: Liechti, George, et al.
Publicado: (2018)

The Association of mRNA Expression of Cell Wall Biosynthesis-Related Genes and the Reversion to Daptomycin (DAP) Susceptibility in DAP Non-Susceptible Methicillin-Resistant Staphylococcus aureus
por: Iwata, Yasunori, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_cdccucrj12k3mj6q0vkfqsbsk8